Drug interactions
Aripiprazole + Papaverine
Severity: Minor
Aripiprazole and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness or dizziness, so combined use might increase sedation or hypotension. Clinical evidence is minimal, and oral papaverine is uncommonly used.
What this interaction means in plain words
Aripiprazole and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
Possible additive central depressant and vasodilatory effects; not well characterized.
What to do
Counsel patients about drowsiness and orthostatic dizziness, particularly at initiation or dose increases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Aripiprazole with Papaverine?
MediHelp rates the interaction as minor. Aripiprazole and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness or dizziness, so combined use might increase sedation or hypotension. Clinical evidence is minimal, and oral papaverine is uncommonly used.
How serious is the interaction between Aripiprazole and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and orthostatic dizziness, particularly at initiation or dose increases.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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