Drug interactions
Aripiprazole + Peginterferon alfa 2b
Severity: Minor
Aripiprazole and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may modestly alter CYP2D6-dependent metabolism of aripiprazole, though the direction and size of any change are unclear. Clinical significance is likely small.
What this interaction means in plain words
Aripiprazole and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2D6; not firmly established.
What to do
Monitor psychiatric response and adverse effects such as akathisia or sedation. Adjust the aripiprazole dose based on clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Peginterferon alfa 2b, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Peginterferon alfa 2b
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Aripiprazole and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may modestly alter CYP2D6-dependent metabolism of aripiprazole, though the direction and size of any change are unclear. Clinical significance is likely small.
How serious is the interaction between Aripiprazole and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and adverse effects such as akathisia or sedation. Adjust the aripiprazole dose based on clinical response.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
