Drug interactions
Aripiprazole + Zolmitriptan
Severity: Moderate
Aripiprazole and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans act as serotonin 5-HT1B/1D agonists, and antipsychotics with serotonergic activity such as aripiprazole have rarely been linked to serotonin toxicity when combined with serotonergic agents. Case-level data are limited, and the risk is considered small for most patients.
What this interaction means in plain words
Aripiprazole and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity, since aripiprazole is a 5-HT1A partial agonist and zolmitriptan is a 5-HT1B/1D agonist; the clinical mechanism is not firmly established.
What to do
Counsel the patient to report agitation, tremor, sweating, fever or muscle rigidity after triptan use. Stop the triptan and treat if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Aripiprazole with Zolmitriptan?
MediHelp rates the interaction as moderate. Aripiprazole and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans act as serotonin 5-HT1B/1D agonists, and antipsychotics with serotonergic activity such as aripiprazole have rarely been linked to serotonin toxicity when combined with serotonergic agents. Case-level data are limited, and the risk is considered small for most patients.
How serious is the interaction between Aripiprazole and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, fever or muscle rigidity after triptan use. Stop the triptan and treat if serotonin toxicity is suspected.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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