Drug interactions
Armodafinil + Atorvastatin
Severity: Minor
Armodafinil and Atorvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a mild CYP3A4 inducer and may reduce atorvastatin plasma concentrations. The lipid-lowering effect could be slightly diminished.
What this interaction means in plain words
Armodafinil and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Atorvastatin belongs to Cardiovascular.
Why it happens
Weak induction of CYP3A4 increases atorvastatin clearance.
What to do
Check lipid profile after starting or stopping armodafinil and adjust the atorvastatin dose if the LDL target is not met.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Atorvastatin?
MediHelp rates the interaction as minor. Armodafinil and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a mild CYP3A4 inducer and may reduce atorvastatin plasma concentrations. The lipid-lowering effect could be slightly diminished.
How serious is the interaction between Armodafinil and Atorvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check lipid profile after starting or stopping armodafinil and adjust the atorvastatin dose if the LDL target is not met.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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