Drug interactions
Armodafinil + Axitinib
Severity: Moderate
Armodafinil and Axitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak to moderate CYP3A4 inducer and may reduce axitinib exposure, potentially compromising antitumor effect. The effect is likely smaller than with strong inducers.
What this interaction means in plain words
Armodafinil and Axitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Axitinib belongs to Oncology.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of axitinib.
What to do
Prefer an alternative with minimal CYP3A4 induction. If coadministered, monitor tumor response and tolerability and adjust the axitinib dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Armodafinil with Axitinib?
MediHelp rates the interaction as moderate. Armodafinil and Axitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak to moderate CYP3A4 inducer and may reduce axitinib exposure, potentially compromising antitumor effect. The effect is likely smaller than with strong inducers.
How serious is the interaction between Armodafinil and Axitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative with minimal CYP3A4 induction. If coadministered, monitor tumor response and tolerability and adjust the axitinib dose accordingly.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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