Drug interactions
Armodafinil + Chloral hydrate
Severity: Minor
Armodafinil and Chloral hydrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is a sedative-hypnotic while armodafinil is a wakefulness-promoting agent, so their effects oppose each other. The net result is unpredictable and may blunt the intended effect of either drug.
What this interaction means in plain words
Armodafinil and Chloral hydrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Chloral hydrate belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
Avoid using armodafinil to counteract a hypnotic dose; monitor response and review need for both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Chloral hydrate?
MediHelp rates the interaction as minor. Armodafinil and Chloral hydrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloral hydrate is a sedative-hypnotic while armodafinil is a wakefulness-promoting agent, so their effects oppose each other. The net result is unpredictable and may blunt the intended effect of either drug.
How serious is the interaction between Armodafinil and Chloral hydrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using armodafinil to counteract a hypnotic dose; monitor response and review need for both drugs.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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