Drug interactions
Armodafinil + Clonazepam
Severity: Minor
Armodafinil and Clonazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is wake-promoting and may partly offset clonazepam sedation, but it should not be relied on to reverse benzodiazepine impairment. Armodafinil is a weak CYP3A4 inducer and may modestly lower clonazepam exposure, potentially reducing its effect.
What this interaction means in plain words
Armodafinil and Clonazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition of sedation and weak CYP3A4 induction by armodafinil increasing clonazepam clearance.
What to do
Monitor for reduced clonazepam efficacy, such as breakthrough seizures or anxiety, and adjust the dose if needed. No routine change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Clonazepam?
MediHelp rates the interaction as minor. Armodafinil and Clonazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is wake-promoting and may partly offset clonazepam sedation, but it should not be relied on to reverse benzodiazepine impairment. Armodafinil is a weak CYP3A4 inducer and may modestly lower clonazepam exposure, potentially reducing its effect.
How serious is the interaction between Armodafinil and Clonazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced clonazepam efficacy, such as breakthrough seizures or anxiety, and adjust the dose if needed. No routine change is required.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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