Drug interactions
Armodafinil + Clozapine
Severity: Moderate
Armodafinil and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak inducer of CYP3A4 and may lower clozapine exposure, which could reduce antipsychotic control. Clozapine is also sedating, so the two drugs have opposing effects on alertness.
What this interaction means in plain words
Armodafinil and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 (and possibly CYP1A2) increases clozapine clearance, plus opposing pharmacodynamic CNS effects.
What to do
Monitor psychiatric symptoms and sedation after starting or stopping armodafinil; consider clozapine plasma levels and dose adjustment if response changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Armodafinil with Clozapine?
MediHelp rates the interaction as moderate. Armodafinil and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak inducer of CYP3A4 and may lower clozapine exposure, which could reduce antipsychotic control. Clozapine is also sedating, so the two drugs have opposing effects on alertness.
How serious is the interaction between Armodafinil and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms and sedation after starting or stopping armodafinil; consider clozapine plasma levels and dose adjustment if response changes.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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