Drug interactions
Armodafinil + Cobimetinib
Severity: Moderate
Armodafinil and Cobimetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobimetinib is a CYP3A4 substrate, and armodafinil is a weak CYP3A4 inducer. Lower cobimetinib exposure could reduce antitumor efficacy, although the effect is expected to be smaller than with strong inducers.
What this interaction means in plain words
Armodafinil and Cobimetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Cobimetinib belongs to Oncology.
Why it happens
Armodafinil induces CYP3A4, increasing cobimetinib metabolism.
What to do
Avoid strong or moderate inducers; with armodafinil, monitor for reduced tumor response and consider an alternative wakefulness agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Armodafinil with Cobimetinib?
MediHelp rates the interaction as moderate. Armodafinil and Cobimetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobimetinib is a CYP3A4 substrate, and armodafinil is a weak CYP3A4 inducer. Lower cobimetinib exposure could reduce antitumor efficacy, although the effect is expected to be smaller than with strong inducers.
How serious is the interaction between Armodafinil and Cobimetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong or moderate inducers; with armodafinil, monitor for reduced tumor response and consider an alternative wakefulness agent.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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