Drug interactions
Armodafinil + Codeine
Severity: Minor
Armodafinil and Codeine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting agent and may offset some sedation from codeine, but it does not remove opioid respiratory depression. Armodafinil may induce CYP3A4, with uncertain effects on codeine.
What this interaction means in plain words
Armodafinil and Codeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Codeine belongs to Musculoskeletal.
Why it happens
Opposing CNS effects; weak CYP3A4 induction by armodafinil is possible.
What to do
No routine change is needed; monitor analgesic response and do not rely on armodafinil to mask opioid sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Codeine?
MediHelp rates the interaction as minor. Armodafinil and Codeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a wakefulness-promoting agent and may offset some sedation from codeine, but it does not remove opioid respiratory depression. Armodafinil may induce CYP3A4, with uncertain effects on codeine.
How serious is the interaction between Armodafinil and Codeine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor analgesic response and do not rely on armodafinil to mask opioid sedation.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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