Drug interactions
Armodafinil + Cyproheptadine
Severity: Minor
Armodafinil and Cyproheptadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine causes drowsiness while armodafinil promotes wakefulness, so their effects may partly oppose each other. No consistent or clinically important interaction is established.
What this interaction means in plain words
Armodafinil and Cyproheptadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Cyproheptadine belongs to Respiratory.
Why it happens
Opposing pharmacodynamic effects on arousal; no established pharmacokinetic mechanism.
What to do
No dose change is generally needed; do not rely on armodafinil to offset antihistamine sedation and assess alertness before driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Cyproheptadine?
MediHelp rates the interaction as minor. Armodafinil and Cyproheptadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyproheptadine causes drowsiness while armodafinil promotes wakefulness, so their effects may partly oppose each other. No consistent or clinically important interaction is established.
How serious is the interaction between Armodafinil and Cyproheptadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; do not rely on armodafinil to offset antihistamine sedation and assess alertness before driving.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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