Drug interactions
Armodafinil + Deflazacort
Severity: Moderate
Armodafinil and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower the concentration of deflazacort's active metabolite, risking reduced efficacy. Deflazacort labeling advises avoiding moderate and strong CYP3A4 inducers.
What this interaction means in plain words
Armodafinil and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Deflazacort belongs to Miscellaneous.
Why it happens
Armodafinil induces CYP3A4, accelerating clearance of the active metabolite of deflazacort.
What to do
Avoid the combination where possible. If used together, monitor clinical response and consider a deflazacort dose increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Armodafinil with Deflazacort?
MediHelp rates the interaction as moderate. Armodafinil and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower the concentration of deflazacort's active metabolite, risking reduced efficacy. Deflazacort labeling advises avoiding moderate and strong CYP3A4 inducers.
How serious is the interaction between Armodafinil and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor clinical response and consider a deflazacort dose increase.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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