Drug interactions
Armodafinil + Diazepam
Severity: Minor
Armodafinil and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may modestly lower diazepam exposure. Armodafinil may also inhibit CYP2C19, which participates in diazepam metabolism, so the net effect is uncertain and probably small.
What this interaction means in plain words
Armodafinil and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 induction and CYP2C19 inhibition by armodafinil altering diazepam metabolism.
What to do
Monitor clinical response to diazepam and adjust the dose if effect is reduced or increased. No routine change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Diazepam?
MediHelp rates the interaction as minor. Armodafinil and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may modestly lower diazepam exposure. Armodafinil may also inhibit CYP2C19, which participates in diazepam metabolism, so the net effect is uncertain and probably small.
How serious is the interaction between Armodafinil and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to diazepam and adjust the dose if effect is reduced or increased. No routine change is needed.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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