Drug interactions
Armodafinil + Docetaxel
Severity: Moderate
Armodafinil and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce docetaxel exposure through CYP3A4 induction, which could lessen antitumor efficacy. Clinical data are limited and the inducing effect is weak to moderate.
What this interaction means in plain words
Armodafinil and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Docetaxel belongs to Oncology.
Why it happens
CYP3A4 induction increases hepatic metabolism of docetaxel.
What to do
Consider an alternative wakefulness agent in patients on docetaxel; if combined, monitor tumor response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Docetaxel
Frequently asked questions
Can I take Armodafinil with Docetaxel?
MediHelp rates the interaction as moderate. Armodafinil and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce docetaxel exposure through CYP3A4 induction, which could lessen antitumor efficacy. Clinical data are limited and the inducing effect is weak to moderate.
How serious is the interaction between Armodafinil and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative wakefulness agent in patients on docetaxel; if combined, monitor tumor response and toxicity.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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