Drug interactions
Armodafinil + Efavirenz
Severity: Minor
Armodafinil and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce armodafinil exposure through enzyme induction, potentially weakening its wakefulness-promoting effect. The reverse effect on efavirenz is likely small.
What this interaction means in plain words
Armodafinil and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing armodafinil metabolism.
What to do
Monitor alertness and increase armodafinil dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Efavirenz?
MediHelp rates the interaction as minor. Armodafinil and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may reduce armodafinil exposure through enzyme induction, potentially weakening its wakefulness-promoting effect. The reverse effect on efavirenz is likely small.
How serious is the interaction between Armodafinil and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor alertness and increase armodafinil dose if the response is inadequate.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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