Drug interactions
Armodafinil + Erlotinib
Severity: Moderate
Armodafinil and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erlotinib is metabolized mainly by CYP3A4, and armodafinil may modestly reduce its exposure. This could weaken antitumor efficacy.
What this interaction means in plain words
Armodafinil and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Erlotinib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases erlotinib clearance.
What to do
Monitor tumor response and tolerability, and consider an alternative to armodafinil if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Armodafinil with Erlotinib?
MediHelp rates the interaction as moderate. Armodafinil and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erlotinib is metabolized mainly by CYP3A4, and armodafinil may modestly reduce its exposure. This could weaken antitumor efficacy.
How serious is the interaction between Armodafinil and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and tolerability, and consider an alternative to armodafinil if possible.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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