Drug interactions
Armodafinil + Fludrocortisone
Severity: Minor
Armodafinil and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is partly metabolized by CYP3A4, so armodafinil may modestly lower its levels. Reduced mineralocorticoid effect could occur in patients dependent on it.
What this interaction means in plain words
Armodafinil and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Fludrocortisone belongs to Endocrine.
Why it happens
Weak CYP3A4 induction increases fludrocortisone clearance.
What to do
Monitor blood pressure, serum sodium and potassium, and adjust the fludrocortisone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Fludrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Armodafinil with Fludrocortisone?
MediHelp rates the interaction as minor. Armodafinil and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone is partly metabolized by CYP3A4, so armodafinil may modestly lower its levels. Reduced mineralocorticoid effect could occur in patients dependent on it.
How serious is the interaction between Armodafinil and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum sodium and potassium, and adjust the fludrocortisone dose if needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
