Drug interactions
Armodafinil + Imipramine
Severity: Moderate
Armodafinil and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil can alter imipramine exposure through opposing effects on CYP enzymes, with possible inhibition of CYP2C19 (which demethylates imipramine) and weak induction of CYP1A2. Net changes in tricyclic levels are unpredictable. The stimulant and sedative effects also oppose each other.
What this interaction means in plain words
Armodafinil and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Armodafinil may inhibit CYP2C19 and induce CYP1A2/CYP3A4, changing imipramine metabolism in an unpredictable direction.
What to do
Monitor for tricyclic adverse effects or loss of effect, and check imipramine levels if clinically indicated. Adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Imipramine?
MediHelp rates the interaction as moderate. Armodafinil and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil can alter imipramine exposure through opposing effects on CYP enzymes, with possible inhibition of CYP2C19 (which demethylates imipramine) and weak induction of CYP1A2. Net changes in tricyclic levels are unpredictable. The stimulant and sedative effects also oppose each other.
How serious is the interaction between Armodafinil and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects or loss of effect, and check imipramine levels if clinically indicated. Adjust the dose accordingly.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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