Drug interactions
Armodafinil + Irinotecan
Severity: Moderate
Armodafinil and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce exposure to irinotecan and its active metabolite SN-38, which could lower anticancer efficacy. CYP3A4 induction diverts irinotecan to inactive metabolites.
What this interaction means in plain words
Armodafinil and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Irinotecan belongs to Oncology.
Why it happens
Armodafinil induces CYP3A4, increasing the oxidative metabolism of irinotecan to inactive metabolites.
What to do
Use an alternative to armodafinil where feasible. If combined, monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Armodafinil with Irinotecan?
MediHelp rates the interaction as moderate. Armodafinil and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce exposure to irinotecan and its active metabolite SN-38, which could lower anticancer efficacy. CYP3A4 induction diverts irinotecan to inactive metabolites.
How serious is the interaction between Armodafinil and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to armodafinil where feasible. If combined, monitor tumor response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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