Drug interactions
Armodafinil + Ivosidenib
Severity: Moderate
Armodafinil and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may reduce armodafinil concentrations, weakening its wakefulness-promoting effect. Ivosidenib also prolongs the QT interval, but armodafinil is not a major concern for that.
What this interaction means in plain words
Armodafinil and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing the metabolism of armodafinil.
What to do
Monitor for reduced wakefulness and increase the armodafinil dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Armodafinil with Ivosidenib?
MediHelp rates the interaction as moderate. Armodafinil and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may reduce armodafinil concentrations, weakening its wakefulness-promoting effect. Ivosidenib also prolongs the QT interval, but armodafinil is not a major concern for that.
How serious is the interaction between Armodafinil and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced wakefulness and increase the armodafinil dose if needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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