Drug interactions
Armodafinil + Ketoconazole
Severity: Minor
Armodafinil and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise armodafinil concentrations by inhibiting its partial CYP3A4 metabolism. Increased exposure could cause more insomnia, anxiety, headache or cardiovascular stimulation, though the effect is usually modest.
What this interaction means in plain words
Armodafinil and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4, which contributes to armodafinil clearance.
What to do
No routine dose change is needed; monitor for increased stimulant adverse effects and reduce the armodafinil dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Ketoconazole?
MediHelp rates the interaction as minor. Armodafinil and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may raise armodafinil concentrations by inhibiting its partial CYP3A4 metabolism. Increased exposure could cause more insomnia, anxiety, headache or cardiovascular stimulation, though the effect is usually modest.
How serious is the interaction between Armodafinil and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for increased stimulant adverse effects and reduce the armodafinil dose if they occur.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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