Drug interactions
Armodafinil + Larotrectinib
Severity: Minor
Armodafinil and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor of CYP3A4, but any rise in armodafinil exposure is unlikely to be clinically important.
What this interaction means in plain words
Armodafinil and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing armodafinil metabolism.
What to do
No routine action needed; watch for increased armodafinil adverse effects such as headache, anxiety or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Larotrectinib
Frequently asked questions
Can I take Armodafinil with Larotrectinib?
MediHelp rates the interaction as minor. Armodafinil and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor of CYP3A4, but any rise in armodafinil exposure is unlikely to be clinically important.
How serious is the interaction between Armodafinil and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; watch for increased armodafinil adverse effects such as headache, anxiety or insomnia.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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