Drug interactions
Armodafinil + Lefamulin
Severity: Moderate
Armodafinil and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A and P-gp substrate, and induction by armodafinil may lower its exposure and cause treatment failure. Labeling advises avoiding strong and moderate inducers unless benefit outweighs risk.
What this interaction means in plain words
Armodafinil and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Lefamulin belongs to Anti Bacterial.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of lefamulin.
What to do
Monitor clinical response to pneumonia treatment and consider holding armodafinil during the short lefamulin course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Armodafinil with Lefamulin?
MediHelp rates the interaction as moderate. Armodafinil and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin is a CYP3A and P-gp substrate, and induction by armodafinil may lower its exposure and cause treatment failure. Labeling advises avoiding strong and moderate inducers unless benefit outweighs risk.
How serious is the interaction between Armodafinil and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to pneumonia treatment and consider holding armodafinil during the short lefamulin course.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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