Drug interactions
Armodafinil + Lorazepam
Severity: Minor
Armodafinil and Lorazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is wake-promoting and may partly offset lorazepam's sedation, but it does not reliably reverse impairment. Armodafinil may also induce CYP3A4, which has little effect on lorazepam because lorazepam is cleared by glucuronidation.
What this interaction means in plain words
Armodafinil and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on alertness; no significant pharmacokinetic interaction is expected for lorazepam.
What to do
Do not rely on armodafinil to counteract benzodiazepine sedation. Monitor the response to each drug and adjust doses based on clinical effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Lorazepam?
MediHelp rates the interaction as minor. Armodafinil and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is wake-promoting and may partly offset lorazepam's sedation, but it does not reliably reverse impairment. Armodafinil may also induce CYP3A4, which has little effect on lorazepam because lorazepam is cleared by glucuronidation.
How serious is the interaction between Armodafinil and Lorazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on armodafinil to counteract benzodiazepine sedation. Monitor the response to each drug and adjust doses based on clinical effect.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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