Drug interactions
Armodafinil + Mavacamten
Severity: Major
Armodafinil and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten depends on CYP2C19 and CYP3A4 for clearance, and altered exposure can cause loss of efficacy or heart failure from excessive systolic impairment. Armodafinil inhibits CYP2C19 and induces CYP3A4, so net effect is unpredictable.
What this interaction means in plain words
Armodafinil and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Armodafinil inhibits CYP2C19 and induces CYP3A4, altering mavacamten metabolism in opposing directions.
What to do
Avoid the combination where possible; if used, monitor LVEF and clinical status closely and adjust mavacamten dosing by echocardiography.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Armodafinil
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Armodafinil with Mavacamten?
MediHelp rates the interaction as major. Armodafinil and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten depends on CYP2C19 and CYP3A4 for clearance, and altered exposure can cause loss of efficacy or heart failure from excessive systolic impairment. Armodafinil inhibits CYP2C19 and induces CYP3A4, so net effect is unpredictable.
How serious is the interaction between Armodafinil and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor LVEF and clinical status closely and adjust mavacamten dosing by echocardiography.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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