Drug interactions
Armodafinil + Nilotinib
Severity: Moderate
Armodafinil and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may reduce nilotinib plasma concentrations, potentially lowering antileukemic efficacy. The magnitude is expected to be modest compared with strong inducers.
What this interaction means in plain words
Armodafinil and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Induction of CYP3A4-mediated metabolism of nilotinib.
What to do
Monitor molecular response to nilotinib and consider nilotinib levels where available. Prefer an alternative to armodafinil if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Armodafinil with Nilotinib?
MediHelp rates the interaction as moderate. Armodafinil and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak CYP3A4 inducer and may reduce nilotinib plasma concentrations, potentially lowering antileukemic efficacy. The magnitude is expected to be modest compared with strong inducers.
How serious is the interaction between Armodafinil and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor molecular response to nilotinib and consider nilotinib levels where available. Prefer an alternative to armodafinil if efficacy appears reduced.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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