Drug interactions
Armodafinil + Nortriptyline
Severity: Minor
Armodafinil and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting drug and may offset the sedation of nortriptyline. Armodafinil can also weakly induce CYP3A4 and inhibit CYP2C19, which is unlikely to alter nortriptyline meaningfully. Clinically significant effects are uncommon.
What this interaction means in plain words
Armodafinil and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Opposing CNS effects; no well-established pharmacokinetic interaction.
What to do
No routine adjustment is needed; monitor mood, sleep and heart rate. Review doses if insomnia or anxiety develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Nortriptyline?
MediHelp rates the interaction as minor. Armodafinil and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a wakefulness-promoting drug and may offset the sedation of nortriptyline. Armodafinil can also weakly induce CYP3A4 and inhibit CYP2C19, which is unlikely to alter nortriptyline meaningfully. Clinically significant effects are uncommon.
How serious is the interaction between Armodafinil and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor mood, sleep and heart rate. Review doses if insomnia or anxiety develops.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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