Drug interactions
Armodafinil + Pazopanib
Severity: Moderate
Armodafinil and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil, a weak CYP3A4 inducer, may reduce pazopanib exposure and potentially its antitumor effect. The effect is expected to be modest.
What this interaction means in plain words
Armodafinil and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Induction of CYP3A4 metabolism of pazopanib.
What to do
Monitor for reduced tumor response and consider an alternative to armodafinil. Do not empirically raise the pazopanib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Armodafinil with Pazopanib?
MediHelp rates the interaction as moderate. Armodafinil and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil, a weak CYP3A4 inducer, may reduce pazopanib exposure and potentially its antitumor effect. The effect is expected to be modest.
How serious is the interaction between Armodafinil and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response and consider an alternative to armodafinil. Do not empirically raise the pazopanib dose.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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