Drug interactions
Armodafinil + Pioglitazone
Severity: Minor
Armodafinil and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is metabolized partly by CYP3A4, and armodafinil is a weak inducer of this enzyme. Exposure to pioglitazone may fall slightly, with little expected effect on glucose control.
What this interaction means in plain words
Armodafinil and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Pioglitazone belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by armodafinil may increase pioglitazone metabolism.
What to do
No dose change is routinely needed. Check glycemic control if armodafinil is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Pioglitazone
Frequently asked questions
Can I take Armodafinil with Pioglitazone?
MediHelp rates the interaction as minor. Armodafinil and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is metabolized partly by CYP3A4, and armodafinil is a weak inducer of this enzyme. Exposure to pioglitazone may fall slightly, with little expected effect on glucose control.
How serious is the interaction between Armodafinil and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Check glycemic control if armodafinil is started or stopped.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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