Drug interactions
Armodafinil + Praziquantel
Severity: Moderate
Armodafinil and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak-to-moderate CYP3A4 inducer and may lower praziquantel exposure. Reduced efficacy against the parasite is possible.
What this interaction means in plain words
Armodafinil and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Praziquantel belongs to Anti Parasitic.
Why it happens
Armodafinil induces CYP3A4, increasing praziquantel metabolism.
What to do
Consider withholding armodafinil during the short praziquantel course. If continued, monitor for treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Praziquantel?
MediHelp rates the interaction as moderate. Armodafinil and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak-to-moderate CYP3A4 inducer and may lower praziquantel exposure. Reduced efficacy against the parasite is possible.
How serious is the interaction between Armodafinil and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding armodafinil during the short praziquantel course. If continued, monitor for treatment response.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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