Drug interactions
Armodafinil + Rasagiline
Severity: Moderate
Armodafinil and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is a MAO-B inhibitor that may lose selectivity at higher doses, and with a stimulant such as armodafinil it may increase blood pressure. Hypertensive reactions are possible but not frequently reported at usual rasagiline doses.
What this interaction means in plain words
Armodafinil and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Additive pressor effects from MAO inhibition and the CNS stimulant action of armodafinil.
What to do
Monitor blood pressure and heart rate after starting or changing doses. Keep rasagiline at recommended doses and avoid combining it with additional sympathomimetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Armodafinil with Rasagiline?
MediHelp rates the interaction as moderate. Armodafinil and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is a MAO-B inhibitor that may lose selectivity at higher doses, and with a stimulant such as armodafinil it may increase blood pressure. Hypertensive reactions are possible but not frequently reported at usual rasagiline doses.
How serious is the interaction between Armodafinil and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or changing doses. Keep rasagiline at recommended doses and avoid combining it with additional sympathomimetics.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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