Drug interactions
Armodafinil + Rifabutin
Severity: Moderate
Armodafinil and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may reduce armodafinil concentrations, potentially diminishing its wake-promoting effect. The inductive effect of rifabutin is less than rifampin but still relevant.
What this interaction means in plain words
Armodafinil and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4, increasing the metabolism of armodafinil.
What to do
Monitor for reduced wakefulness benefit and consider increasing the armodafinil dose within the labeled range. Reassess the dose if rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Armodafinil with Rifabutin?
MediHelp rates the interaction as moderate. Armodafinil and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may reduce armodafinil concentrations, potentially diminishing its wake-promoting effect. The inductive effect of rifabutin is less than rifampin but still relevant.
How serious is the interaction between Armodafinil and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced wakefulness benefit and consider increasing the armodafinil dose within the labeled range. Reassess the dose if rifabutin is stopped.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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