Drug interactions
Armodafinil + Siponimod
Severity: Moderate
Armodafinil and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil, a CYP3A4 inducer, may lower siponimod exposure and reduce its effect on multiple sclerosis. Labeling recommends avoiding moderate or strong CYP3A4 inducers in patients with certain CYP2C9 genotypes.
What this interaction means in plain words
Armodafinil and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Why it happens
Armodafinil induces CYP3A4, increasing the clearance of siponimod, which is metabolized by CYP2C9 and CYP3A4.
What to do
Avoid the combination in CYP2C9*1/*3 and *2/*3 patients. Otherwise monitor for reduced disease control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Armodafinil with Siponimod?
MediHelp rates the interaction as moderate. Armodafinil and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil, a CYP3A4 inducer, may lower siponimod exposure and reduce its effect on multiple sclerosis. Labeling recommends avoiding moderate or strong CYP3A4 inducers in patients with certain CYP2C9 genotypes.
How serious is the interaction between Armodafinil and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in CYP2C9*1/*3 and *2/*3 patients. Otherwise monitor for reduced disease control.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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