Drug interactions
Armodafinil + Sunitinib
Severity: Moderate
Armodafinil and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil, a weak CYP3A4 inducer, may lower sunitinib and its active metabolite exposure, possibly reducing antitumor efficacy. The effect is expected to be smaller than with strong inducers.
What this interaction means in plain words
Armodafinil and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Induction of CYP3A4 metabolism of sunitinib.
What to do
Prefer an alternative to armodafinil if possible. If used, monitor tumor response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Armodafinil with Sunitinib?
MediHelp rates the interaction as moderate. Armodafinil and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil, a weak CYP3A4 inducer, may lower sunitinib and its active metabolite exposure, possibly reducing antitumor efficacy. The effect is expected to be smaller than with strong inducers.
How serious is the interaction between Armodafinil and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to armodafinil if possible. If used, monitor tumor response and tolerability.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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