Drug interactions
Armodafinil + Vinorelbine
Severity: Minor
Armodafinil and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine is cleared by CYP3A4. Armodafinil is a weak inducer, so a small decrease in vinorelbine exposure is theoretically possible but unlikely to matter clinically.
What this interaction means in plain words
Armodafinil and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Vinorelbine belongs to Oncology.
Why it happens
Weak CYP3A4 induction by armodafinil may increase vinorelbine metabolism.
What to do
No routine change is needed. Follow standard hematologic monitoring and response assessment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Vinorelbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Vinorelbine
Frequently asked questions
Can I take Armodafinil with Vinorelbine?
MediHelp rates the interaction as minor. Armodafinil and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinorelbine is cleared by CYP3A4. Armodafinil is a weak inducer, so a small decrease in vinorelbine exposure is theoretically possible but unlikely to matter clinically.
How serious is the interaction between Armodafinil and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Follow standard hematologic monitoring and response assessment.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
