Drug interactions
Artemether + Chlorpromazine
Severity: Major
Artemether and Chlorpromazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether and chlorpromazine can each lengthen the QT interval. Together they raise the risk of clinically significant arrhythmia, particularly with electrolyte disturbance or heart disease.
What this interaction means in plain words
Artemether and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hERG channel blockade leading to QT prolongation.
What to do
Avoid concurrent use if an alternative exists. Otherwise obtain an ECG before and during treatment and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Artemether with Chlorpromazine?
MediHelp rates the interaction as major. Artemether and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether and chlorpromazine can each lengthen the QT interval. Together they raise the risk of clinically significant arrhythmia, particularly with electrolyte disturbance or heart disease.
How serious is the interaction between Artemether and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if an alternative exists. Otherwise obtain an ECG before and during treatment and correct electrolyte abnormalities.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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