Drug interactions
Artemether + Leuprolide
Severity: Moderate
Artemether and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether, usually given with lumefantrine, can prolong the QT interval. Leuprolide may add to QT prolongation via androgen deprivation, increasing the risk of arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Artemether and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG and correct electrolytes if risk factors are present, and monitor for palpitations or syncope during the antimalarial course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Artemether with Leuprolide?
MediHelp rates the interaction as moderate. Artemether and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether, usually given with lumefantrine, can prolong the QT interval. Leuprolide may add to QT prolongation via androgen deprivation, increasing the risk of arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Artemether and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolytes if risk factors are present, and monitor for palpitations or syncope during the antimalarial course.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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