Drug interactions
Artemether / lumefantrine + Avanafil
Severity: Minor
Artemether / lumefantrine and Avanafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a weak CYP3A4 inducer and may lower avanafil concentrations. This could reduce erectile response during the short antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Avanafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Artemether induces CYP3A4, modestly increasing avanafil metabolism.
What to do
Monitor erectile response and consider deferring avanafil use until the antimalarial course is complete if efficacy is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Avanafil?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Avanafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a weak CYP3A4 inducer and may lower avanafil concentrations. This could reduce erectile response during the short antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Avanafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor erectile response and consider deferring avanafil use until the antimalarial course is complete if efficacy is poor.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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