Drug interactions
Artemether / lumefantrine + Enzalutamide
Severity: Major
Artemether / lumefantrine and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and lowers the plasma concentrations of artemether and lumefantrine, both CYP3A4 substrates. This can cause failure of malaria treatment and recrudescence. Labeling advises against use with strong inducers.
What this interaction means in plain words
Artemether / lumefantrine and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 by enzalutamide increases the metabolism of artemether and lumefantrine.
What to do
Avoid the combination and choose an antimalarial not dependent on CYP3A4. If it cannot be avoided, monitor closely for treatment failure and parasitological response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Enzalutamide?
MediHelp rates the interaction as major. Artemether / lumefantrine and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and lowers the plasma concentrations of artemether and lumefantrine, both CYP3A4 substrates. This can cause failure of malaria treatment and recrudescence. Labeling advises against use with strong inducers.
How serious is the interaction between Artemether / lumefantrine and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antimalarial not dependent on CYP3A4. If it cannot be avoided, monitor closely for treatment failure and parasitological response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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