Drug interactions
Artemether / lumefantrine + Prochlorperazine
Severity: Major
Artemether / lumefantrine and Prochlorperazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and artemether/lumefantrine labeling advises against use with other QT-prolonging drugs. The combination increases the risk of torsades de pointes.
What this interaction means in plain words
Artemether / lumefantrine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination and use an antiemetic with less QT effect. If it cannot be avoided, obtain an ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Artemether / lumefantrine with Prochlorperazine?
MediHelp rates the interaction as major. Artemether / lumefantrine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, and artemether/lumefantrine labeling advises against use with other QT-prolonging drugs. The combination increases the risk of torsades de pointes.
How serious is the interaction between Artemether / lumefantrine and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic with less QT effect. If it cannot be avoided, obtain an ECG and correct electrolytes.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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