Drug interactions
Asciminib + Ritonavir
Severity: Moderate
Asciminib and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir raises asciminib exposure. Increased levels may cause more toxicity, particularly at higher doses.
What this interaction means in plain words
Asciminib and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Strong CYP3A4 inhibition by ritonavir reduces asciminib metabolism.
What to do
Monitor for adverse effects such as myelosuppression and pancreatitis. Consider asciminib dose reduction if toxicity occurs, especially at 200 mg twice daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asciminib
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Asciminib with Ritonavir?
MediHelp rates the interaction as moderate. Asciminib and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir raises asciminib exposure. Increased levels may cause more toxicity, particularly at higher doses.
How serious is the interaction between Asciminib and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as myelosuppression and pancreatitis. Consider asciminib dose reduction if toxicity occurs, especially at 200 mg twice daily.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Clarithromycin, Dihydroergotamine, Ergotamine. The full list is on the Asciminib page.
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