Drug interactions
Asciminib + Rosuvastatin
Severity: Moderate
Asciminib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asciminib inhibits OATP1B and BCRP, both of which govern rosuvastatin disposition. Rosuvastatin exposure may rise, increasing the risk of myopathy.
What this interaction means in plain words
Asciminib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B and BCRP transporters, reducing hepatic uptake and efflux of rosuvastatin.
What to do
Monitor for muscle toxicity and use the lowest effective rosuvastatin dose; reduce the dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Asciminib
Frequently asked questions
Can I take Asciminib with Rosuvastatin?
MediHelp rates the interaction as moderate. Asciminib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asciminib inhibits OATP1B and BCRP, both of which govern rosuvastatin disposition. Rosuvastatin exposure may rise, increasing the risk of myopathy.
How serious is the interaction between Asciminib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle toxicity and use the lowest effective rosuvastatin dose; reduce the dose if symptoms develop.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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