Drug interactions
Asciminib + Warfarin
Severity: Moderate
Asciminib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asciminib can inhibit CYP2C9 at therapeutic exposures, which may increase exposure to S-warfarin, the more potent enantiomer. This can raise the INR and the risk of bleeding.
What this interaction means in plain words
Asciminib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Asciminib inhibits CYP2C9, reducing the metabolism of S-warfarin.
What to do
Monitor INR more frequently after starting or stopping asciminib and reduce the warfarin dose if INR rises. Consider alternative anticoagulation if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asciminib and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Asciminib
Frequently asked questions
Can I take Asciminib with Warfarin?
MediHelp rates the interaction as moderate. Asciminib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asciminib can inhibit CYP2C9 at therapeutic exposures, which may increase exposure to S-warfarin, the more potent enantiomer. This can raise the INR and the risk of bleeding.
How serious is the interaction between Asciminib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently after starting or stopping asciminib and reduce the warfarin dose if INR rises. Consider alternative anticoagulation if control is unstable.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
