Drug interactions
Asenapine + Dihydroergotamine
Severity: Moderate
Asenapine and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonergic and dopaminergic receptors, and case-based concern exists for serotonin toxicity or neuroleptic malignant syndrome. Dihydroergotamine can also cause vasoconstriction and the clinical significance of this combination is uncertain.
What this interaction means in plain words
Asenapine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Overlapping serotonin receptor activity with dopamine blockade; the mechanism is largely theoretical and not firmly established.
What to do
Monitor for agitation, hyperthermia, rigidity, tremor and autonomic instability after starting or changing doses. Stop treatment and give supportive care if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Asenapine with Dihydroergotamine?
MediHelp rates the interaction as moderate. Asenapine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on serotonergic and dopaminergic receptors, and case-based concern exists for serotonin toxicity or neuroleptic malignant syndrome. Dihydroergotamine can also cause vasoconstriction and the clinical significance of this combination is uncertain.
How serious is the interaction between Asenapine and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, rigidity, tremor and autonomic instability after starting or changing doses. Stop treatment and give supportive care if serotonin syndrome or NMS is suspected.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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