Drug interactions
Asenapine + Ergotamine
Severity: Moderate
Asenapine and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine has serotonergic and dopaminergic activity, and its combination with antipsychotics has been associated with theoretical serotonergic or neuroleptic malignant syndrome concerns. Ergotamine also causes vasoconstriction, and asenapine is a weak CYP1A2 substrate, so the evidence of a clear interaction is limited.
What this interaction means in plain words
Asenapine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopaminergic effects; not firmly established.
What to do
Counsel the patient to report agitation, fever, rigidity or autonomic instability. Stop ergotamine and seek urgent care if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asenapine and Ergotamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Asenapine with Ergotamine?
MediHelp rates the interaction as moderate. Asenapine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine has serotonergic and dopaminergic activity, and its combination with antipsychotics has been associated with theoretical serotonergic or neuroleptic malignant syndrome concerns. Ergotamine also causes vasoconstriction, and asenapine is a weak CYP1A2 substrate, so the evidence of a clear interaction is limited.
How serious is the interaction between Asenapine and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, fever, rigidity or autonomic instability. Stop ergotamine and seek urgent care if these occur.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
