Drug interactions
Asenapine + Fenfluramine
Severity: Moderate
Asenapine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine acts by increasing serotonin release and activating serotonin receptors, and asenapine strongly blocks several serotonin receptors, so it may reduce seizure control benefit. Additive sedation may also occur.
What this interaction means in plain words
Asenapine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at serotonin receptors, plus additive CNS depression.
What to do
Monitor seizure frequency and sedation when the two are used together. Adjust doses based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Asenapine with Fenfluramine?
MediHelp rates the interaction as moderate. Asenapine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine acts by increasing serotonin release and activating serotonin receptors, and asenapine strongly blocks several serotonin receptors, so it may reduce seizure control benefit. Additive sedation may also occur.
How serious is the interaction between Asenapine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and sedation when the two are used together. Adjust doses based on clinical response.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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