Drug interactions
Asenapine + Glipizide
Severity: Moderate
Asenapine and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine may cause hyperglycemia or worsen glucose tolerance, which can counteract the effect of glipizide in patients with diabetes. Glycemic control may therefore deteriorate after asenapine is started.
What this interaction means in plain words
Asenapine and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Glipizide belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose sulfonylurea glucose lowering; the exact mechanism is not fully established.
What to do
Check fasting glucose and HbA1c at baseline and regularly during therapy. Increase glipizide or change the regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Glipizide
Frequently asked questions
Can I take Asenapine with Glipizide?
MediHelp rates the interaction as moderate. Asenapine and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine may cause hyperglycemia or worsen glucose tolerance, which can counteract the effect of glipizide in patients with diabetes. Glycemic control may therefore deteriorate after asenapine is started.
How serious is the interaction between Asenapine and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and regularly during therapy. Increase glipizide or change the regimen if control worsens.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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