Drug interactions
Asenapine + Hydroxychloroquine
Severity: Moderate
Asenapine and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, increasing the risk of torsades de pointes, particularly with heart disease or electrolyte disturbance.
What this interaction means in plain words
Asenapine and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive QT prolongation via cardiac potassium channel blockade.
What to do
Obtain baseline ECG and monitor QTc, and correct potassium and magnesium. Choose a lower-risk antipsychotic if QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Asenapine and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, increasing the risk of torsades de pointes, particularly with heart disease or electrolyte disturbance.
How serious is the interaction between Asenapine and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and monitor QTc, and correct potassium and magnesium. Choose a lower-risk antipsychotic if QT risk factors exist.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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