Drug interactions
Asenapine + Methamphetamine
Severity: Minor
Asenapine and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a weak CYP2D6 inhibitor and methamphetamine is partly metabolised by CYP2D6, so methamphetamine exposure could rise slightly. Any clinical effect is probably small and the evidence is mostly theoretical.
What this interaction means in plain words
Asenapine and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6 by asenapine may modestly reduce methamphetamine metabolism.
What to do
No dose change is usually needed; monitor for increased stimulant effects such as tachycardia, agitation or hypertension when starting asenapine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Methamphetamine?
MediHelp rates the interaction as minor. Asenapine and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine is a weak CYP2D6 inhibitor and methamphetamine is partly metabolised by CYP2D6, so methamphetamine exposure could rise slightly. Any clinical effect is probably small and the evidence is mostly theoretical.
How serious is the interaction between Asenapine and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for increased stimulant effects such as tachycardia, agitation or hypertension when starting asenapine.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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