Drug interactions
Bosentan + Midostaurin
Severity: Major
Bosentan and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin is metabolized mainly by CYP3A4, and induction can substantially lower its concentrations. Reduced exposure may compromise its antileukemic activity.
What this interaction means in plain words
Bosentan and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Midostaurin belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, accelerating midostaurin clearance.
What to do
Avoid the combination where possible and consider an alternative to bosentan. If it is unavoidable, monitor for reduced leukemia response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Bosentan with Midostaurin?
MediHelp rates the interaction as major. Bosentan and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin is metabolized mainly by CYP3A4, and induction can substantially lower its concentrations. Reduced exposure may compromise its antileukemic activity.
How serious is the interaction between Bosentan and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider an alternative to bosentan. If it is unavoidable, monitor for reduced leukemia response.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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